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However, because cytochrome P-450 enzymes are involved in a variety of synthetic processes (the formation of testosterone and other steroids) and detoxification (ethanol), the potential exists for certain reversible side effects related to inactivation of this system at doses as high as those that are needed in ketoconazole treatment for onychomycosis ().
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If patients drink a cola beverage before they take these drugs, they may acidify their stomach and thereby increase drug absorption by up to 60 percent.
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